Maureen R. Hanson is Liberty Hyde Bailey Professor in the Department of Molecular Biology & Genetics. She received a B.S. degree at Duke University and a Ph.D. in Cell and Developmental Biology from Harvard University. After completing an NIH postdoctoral fellowship at Harvard, she joined the faculty of the Biology Department at University of Virginia. She moved to Cornell as Associate Professor and was promoted to Professor in 1991. She is presently a member of the graduate Fields of Genetics and Development, Plant Biology, and Biochemistry, Molecular, and Cell Biology. She has previously served as Associate Director of the Cornell Biotechnology Program and Director of the Cornell Plant Science Center. She is currently Director for the Center for Enervating Neuroimmune Disease.
Dr. Hanson has two different research programs, related through their dependence on modern methods for examining genome sequences and gene expression. Her research in plant biology has always focused on the genome-containing organelles of plants, chloroplasts and mitochondria. Reflecting their prokaryotic origins, gene expression in these organelles differs from that of nuclear genes. In particular, organelle genes are often organized in operons that undergo considerable post-transcriptional processing, including RNA editing. The nuclear genome exerts significant control of organelle gene expression through the action of nuclear-encoded proteins targeted to the organelle. Research goals include identification of the components of the organelle RNA editing apparatus and an RNA/protein complex that suppresses the expression of an abnormal mitochondrial protein. Another study utilizes synthetic biology methods to introduce CO2-concentrating microcompartments into chloroplasts. A third project concerns engineering of the carbon-fixing enzyme Rubisco in chloroplasts in order to enhance the efficiency of photosynthesis. A second research area is the pathophysiology of the human illness Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME). Individuals with this illness often have evidence of immune system activation and dysfunction. One current project is examining metabolism of immune cells and metabolites in plasma. Another project aims to identify differences in gene expression and cargo of extracellular vesicles at baseline and following exercise in healthy and in subjects diagnosed with ME/CFS
Dr. Hanson teaches lab sessions on methods for producing transgenic organisms and on fluorescence microscopy. She participates in a lecture class concerning genetic engineering for basic research and practical application. She is the coordinator and lecturer in a team-taught class on ethics in biological research.
- Mandarano, A. H., Giloteaux, L., Keller, B. A., Levine, S. M., & Hanson, M. R. (2018). Eukaryotes in the gut microbiota in myalgic encephalomyelitis/chronic fatigue syndrome. PeerJ. 6:e4282.
- Germain, A., Ruppert, D., Levine, S. M., & Hanson, M. R. (2017). Metabolic profiling of a myalgic encephalomyelitis/chronic fatigue syndrome discovery cohort reveals disturbances in fatty acid and lipid metabolism. Molecular BioSystems. 13:371-379.
- Occhialini, A., Myat, L. T., Andralojc, P. J., Hanson, M. R., & Parry, M. A. (2016). Transgenic tobacco plants with improved cyanobacterial Rubisco expression but no extra assembly factors grow at near wild-type rates if provided with elevated CO2. The Plant Journal. 85:148-160.
- Sun, T., Bentolila, S., & Hanson, M. R. (2016). The unexpected diversity of plant organelle RNA editosomes. Trends in Plant Science. 21:962-973.
- Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R., & Hanson, M. R. (2016). Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome. Microbiome. 4:30.
- Hanson, M. R., Lin, M. T., Carmo-Silva, E., & Parry, M. A. (2016). Towards engineering carboxysomes into C3 plants. The Plant Journal. 87:38-50.
- Billing-Ross, P., Germain, A., Ye, K., Keinan, A., Gu, Z., & Hanson, M. R. (2016). Mitochondrial DNA variants correlate with symptoms in myalgic encephalomyelitis/chronic fatigue syndrome. Journal of Translational Medicine. 14.
- Sun, T., Shi, X., Friso, G., van Wijk, K., Bentolila, S., & Hanson, M. R. (2015). A zinc finger motif-containing protein is essential for chloroplast RNA editing. PLOS Genetics. 11:23 pages.
- Wagoner, J. A., Tao, S., Hanson, M. R., & Lin, L. (2015). Cytidine deaminase motifs within the DYW domain of two pentatricopeptide repeat-containing proteins are required for site-specific chloroplast RNA editing. JBC: Journal of Biological Chemistry. 290:2957-68.
- Lin, M. T., Occhialini, A., Andralojc, P. J., Parry, M. A., & Hanson, M. R. (2014). A faster Rubisco with potential to increase photosynthesis in crops. Nature. 513:547-50.
Presentations and Activities
- Current clinical diagnostic criteria and knowledge of the biological basis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. Grand Rounds. February 2018. Cayuga Medical Center. Ithaca, NY.
- Engineering the Chloroplast Genome for Improved Photosynthesis. 5TH Plant Genomics & Gene Editing Congress. November 2017. Global Engage, Inc.. Philadelphia, PA.
- Biological alterations in ME/CFS: microbiome, exercise physiology, metabolism. Swedish ME Association Patient Meeting. October 2017. Malmo, Sweden.
- ME/CFS Research at the Cornell Center for Enervating Neuroimmune Disease. SMCI’s Second Annual Discovery Forum. October 2017. Solve ME/CFS Initiative. Washington D.C., United States.
- Probing metabolism in ME/CFS. Community Symposium on the Molecular Basis of ME/CFS. August 2017. Open Medicine Foundation. Palo Alto, CA.
- Engineering Carboxysomes into C3 Plants. Annual Meeting, American Society of Plant Biology. June 2017. American Society of Plant Biology. Honolulu, Hawaii.
- Metabolomics and ME/CFS. InvestinME Colloquium. June 2017. InvestinME. London, England.
- A complex RNA editing apparatus repairs organelle transcripts. 10th International Conference for Plant Mitochondrial Biology. May 2017. Zhejiang University. Hangzhou, China.
- Prospects for improving C3 plant photosynthesis with a cyanobacterial carbon-concentrating mechanism. UC Davis Plant Science Symposium. April 2017. Dupont Pioneer and UC Davis. Davis, CA.
- Diverse composition of RNA editosomes. Gordon Conference on RNA Editing. March 2017. Gordon Conference Organization. Ventura, CA.