My research focuses on molecular regulatory mechanisms of plant senescence and dimensional control of gene expression in plants. This research has implications on the yields of certain crops and their storage after harvest.
Leaf senescence is an integral part of plant development that limits the yield of certain crops. (Yellowing leaves lose their photosynthetic capability.) Senescence also contributes to much of the postharvest loss of vegetable crops. The long-term goal of my research is to unveil the molecular regulatory mechanisms underlying the leaf yellowing process or senescence so that we can use the molecular findings to devise ways to manipulate senescence genetically for agricultural improvement. Various molecular, genetic and genomic approaches have been employed to clone and analyze genes that are either driving or retarding the senescence program in Arabidopsis and tobacco plants. My ongoing projects include (i) functional characterization of a subset of senescence-specific transcription factor genes in Arabidopsis, (ii) networking leaf senescence transcription factors in Arabidopsis, (iii) map-based positional cloning and characterization of genetic loci that regulate expression of senescence-specific genes, and (iv) development and use of TASSEL tagging system for cloning senescence-inhibiting genes in tobacco plants.
Outreach and Extension Focus
I have actively participated in numerous outreach activities to show stakeholders and business sectors how research on senescence is important, how our senescence-manipulating technologies have been developed/invented, and how our technologies can be best utilized for our daily life and society.
I teach four courses directly related to my research: Hort 425 (Postharvest Biology of Horticultural Crops), Hort 625.01 (Advanced Postharvest Physiology), Hort 625.02 / BioPl 453.06 (Plant Senescence), and BioPL 744 (Graduate Research Seminars in Plant Cell & Molecular Biology)
- Gan, S., & Hörtensteiner, S. (2013). Frontiers in plant senescence research: from bench to bank. Plant Molecular Biology. 82:503-504.
- Zhang, K., Halitschke, R., Yin, C., Liu, C., & Gan, S. (2013). Salicylic acid 3-hydroxylase regulates Arabidopsis leaf longevity by mediating salicylic acid catabolism. PNAS: Proceedings of the National Academy of Sciences of the United States of America. 110:14807-14812.
- Hou, K., Wu, W., & Gan, S. (2013). SAUR36, a Small Auxin Up RNA gene, is involved in promotion of leaf senescence in Arabidopsis. Plant Physiology. 161:1002-1009.
- Zhang, K., & Gan, S. (2012). An abscisic acid-AtNAP transcription factor-SAG113 protein phosphatase 2C regulatory chain for controlling dehydration in senescing Arabidopsis leaves. Plant Physiology. 158:961-969.
- Davies, P. J., & Gan, S. (2012). Towards an integrated view of monocarpic plant senescence. Russian Journal of Plant Physiology. 59:476-478.
- Zhu, P., Xu, L., Zhang, C., Toyoda, H., & Gan, S. (2012). Ethylene produced by Botrytis cinerea can affect early fungal development and can be used as a marker for infection during storage of grapes. Postharvest Biology and Technology. 66:23-29.
- Guo, Y., & Gan, S. (2012). Convergence and divergence in gene expression profiles induced by developmental leaf senescence and 27 senescence-promoting hormonal, pathological and environmental stress treatments. Plant, Cell & Environment. 35:644-655.
- Zhang, K., Xia, X., Zhang, Y., & Gan, S. (2012). An ABA-regulated and Golgi-localized protein phosphatase controls water loss during leaf senescence in Arabidopsis. The Plant Journal. 69:667-678.
- Gan, S. (2012). Regulation of senescence by plant growth substances. In: Plant Hormones: Function and Molecular Mechanism Zhihong Xu and Hongwei Xue (ed.),.